FIGURE 5.

Mutational frequencies (A) and distribution of mutational hotspots (B) of TP53 in prostate cancer across different countries. (A) Represents the mutational frequencies of TP53 in prostate cancer as obtained from the International Cancer Genome Consortium (ICGC) data portal were plotted across different countries – United States, United Kingdom, Germany, France, China, and Canada. The mutational frequency is defined as the proportion of prostate tissue samples with TP53 mutations with respect to total prostate tissue samples collected. (B) Illustrates the distribution of TP53 mutational hotspots along with their frequencies in prostate cancer samples across countries. In total six mutational hotspots are indicated (Tyr163Cys, Met237Ile, Arg273Cys, Arg248Gln, Cys238Phe, and Cys176Trp).