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. 2020 Oct 23;11:578345. doi: 10.3389/fgene.2020.578345

FIGURE 6.

FIGURE 6

Clinical and structural consequences of mutational events of TP53, PIK3CA, and CDK1 genes. (A) Shows that distribution of the top 20 mutated genes across eight different breast cancer subtypes (ER PR Positive – BC, ER PR HER Positive – BC, ER Positive – BC, ER HER Positive – BC, Triple Negative – BC, PR Positive – BC, PR HER Positive – BC and HER Positive – BC) in the form of Upset Venn diagram. The Venn diagram was based on the data obtained from COSMIC. Two genes – TP53 and PIK3CA were found to be commonly mutated in seven of the eight subtypes (represented by the last two vertical bars). The most commonly mutated residues in TP53 and PIK3CA are R248L (B) and E545D (C), respectively, in triple-negative breast cancer. The consequences of these mutations on the 3D structure that can consequently alter the function of TP53 (B) and PIK3CA (C) proteins are shown. The survival curves of the liver (D) and cervical (F) cancer patients with high and low expression of CDK1 are shown. These plots were generated by The Pathology Atlas. High CDK1 expression was annotated as unfavorable (D) and favorable in terms of prognosis for liver and cervical (F) cancer. The protein levels validation of CDK1 expression in liver (E) and cervical (G) cancer tissues measured by the IHC technique are shown. The antibodies used for the IHC stating are indicated for both cancer tissues.