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. 2020 Oct 23;8:573297. doi: 10.3389/fchem.2020.573297

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Copyright © 2020 Li, Teng and Min.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of EGCG delivery systems: (1) grafting EGCG on the surface of the nanoparticles to enhance cellular uptake of as-obtained nanovehicles; (2) surface functionalization with specific molecules (chitosan, folic acid, gallic acid, and chlorogenic acid) to enhance stability, cellular uptake, and drug release properties of the nanovehicles; (3) targeted molecular modification by peptides or aptamers to target specific cancer cell receptors; (4) construction of multi-modal therapeutics co-delivery systems to realize EGCG-involved cancer combination therapy.