Figure 9.

The average number of lipofuscin granules and melanosomes calculated from 35 RPE cells of Abca4^−/− and 35 RPE cells of WT from three eyes of three mice of each strain. (A) The average number of lipofuscin granules per RPE cells was more than three times greater in Abca4^−/− compared to WT control. (B) Lipofuscin granules (in picoliters) were more than twice as dense in Abca4^−/− mice. (C) Conversely, the average number of melanosomes per RPE cells in Abca4^−/− was roughly half what was seen in WT, and (D) the density of melanosomes (in picoliters) in Abca4^−/− was roughly half what was seen in WT. Error bars represent standard errors (*P < 0.001, **P < 0.005, ***P < 0.01, and ****P < 0.01).