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Autophagy has the effect of inhibiting AD. Firstly, MYR can promote autophagy by inhibiting phosphorylation of mTOR; Secondly, DMY can inhibit mTOR through ERK1/2 pathway, AMPK-PGC-1α-Sirt3 pathway, and PI3K/PDK 1/Akt pathway, ultimately promote autophagy; Thirdly, DMY can also promote autophagy through the Keap-1/Nrf2, ROS-NF-κB and MALAT1-TFEB pathways.
