Figure 5.

Operational Taxonomic Units (OTU's) differentially abundant in gut microbiota of newborns and infants of mothers with or without GDM. Volcano plot of estimated log₂ fold difference in OTU abundance according to maternal GDM status in newborns [(A) n = 34 of mothers with GDM and n = 72 of mothers with normal gestational glucose regulation, at 1 week of life] and infants [(B) n = 42 of mothers with GDM and n = 81 of mothers with normal gestational glucose regulation, at an average of 8.8 months of life) and corresponding Benjamin-Hochberg adjusted P-values (Q) from negative binomial Wald tests as implemented in the DESeq2 R package. Prevalence indicates percentage of children in which a given OTU is present. Abundance indicates mean relative abundance (reads per million). Taxonomic annotation of OTUs differentially abundant at a 10% false discovery rate is given at the genus level. Detailed information is presented in Supplementary Table 3.