Table 1.
Familial syndromes associated with meningiomas.
| Familial syndrome | Gene | Chromosome locus |
|---|---|---|
| Neurofibromatosis type 2 | NF2 | 22q12 |
| Familial schwannomatosis | SMARCB1 | 22q11.23 |
| Multiple spinal meningiomas | SMARCE1 | 17q21.2 |
| BAP1 tumor predisposition syndrome | BAP1 | 3p21.1 |
| Gorlin syndrome (nevoid basal cell carcinoma syndrome) | PTCH1 | 9q22.3 |
| SUFU | 10q24.32 | |
| Familial multiple meningiomas | SUFU | 10q24.32 |
| Rubinstein-Taybi syndrome | CREBBP | 16p13.3 |
| Cowden disease | PTEN | 10q23.31 |
| Li-Fraumeni syndrome | TP53/CHEK2 | 17p13.1/22q12.1 |
| Gardner syndrome | APC | 5q21-22 |
| Multiple endocrine neoplasia type 1 | MEN | 11q13 |
| Werner syndrome | LMNA | 1q21.1 |
Specific gene and chromosome locus are illustrated in the table.