Table 4.
Genes associated with meningiomas with corresponding chromosomal location and product (86).
| Gene | Full name | Locus | Product |
|---|---|---|---|
| NF2 | Neurofibromin 2 | 22q12.2 | Merlin |
| TRAF7 | TNF receptor-associated factor 7 | 16p13.3 | TNF receptor-associated factor 7 |
| KLF4 | Kruppel-like factor 4 | 9p31 | Kruppel-like factor 4 |
| AKT1 | v-Akt murine thymoma viral oncogene homolog 1 | 14q32.33 | AKT1 kinase (serine/threonine protein kinase) |
| SMO | Smoothened, frizzled class receptor | 7p32.1 | Smoothened, G protein-coupled receptor |
| PIK3CA | Phosphadidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | 3q26.32 | Catalytic subunit of kinase, PI3K |
| POLR2A | RNA polymerase II subunit A | 17p13.1 | RNA polymerase II subunit A |
| BAP1 | BRCA1-associated protein 1 | 3p21.1 | Ubiquitin carboxyl-terminal hydrolase 1 |
| SMARCB1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | 22q11.23 | Subunit of SWI/SNF complex |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | 17q21.2 | Subunit of SWI/SNF complex |
| BRAF V600E | B-Raf proto-oncogene | 7q34 | Serine/threonine kinase |
| NOTCH2 | Notch receptor 2 | 1p12 | Notch2 (notch receptor family) |
| PTEN | Phosphatase and tensin homolog | 10q23.31 | Phosphatidylinositol-3,4,5-triphosphate 3-phosphatase |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | 9p21.3 | p16(INK4A), p14(ARF) |
| CDKN2B | Cyclin-dependent kinase inhibitor 2B | 9p21.3 | p15(INK4B) |