Table 2.
Clinical Eye Examination Parameters Determined via Pachymetry, STT, and Applanation Tonometry
| Pachymetry CCT (µm) | STT Tear Flow (mm) | Applanation Tonometry IOP (mm Hg) | |||||
|---|---|---|---|---|---|---|---|
| Groups | Treatment to the Eye | Study Time Day-3 | Study Time Day-7 | Study Time Day-3 | Study Time Day-7 | Study Time Day-3 | Study Time Day-7 |
| I (Naive) | No treatment | 363.0 ± 5.1 | 367.4 ± 4.2 | 10.0 ± 0.7 | 10.2 ± 0.6 | 10.7 ± 0.7 | 9.0 ± 0.8 |
| II (TED) | TED (without SM exposure) | 365.0 ± 5.0ns (naive vs. TED) | 372.6 ± 7.7 ns (naive vs. TED) | 9.5 ± 0.8ns (naive vs. TED) | 8.4 ± 0.5ns (naive vs. TED) | 8.2 ± 0.9ns (naive vs. TED) | 8.6 ± 0.7ns (naive vs. TED) |
| III (SM) | SM vapor | 515.0 ± 5.6**** (naive vs. SM) | 540.2 ± 14.0**** (naive vs. SM) | 27.5 ± 0.5**** (naive vs. SM) | 25.8 ± 1.3**** (naive vs. SM) | 9.7 ± 1.0ns (naive vs. SM) | 8.4 ± 1.1ns (naive vs. SM) |
| IV (SM+TED) | SM vapor + TED | 420.0 ± 5.2**** (SM vs. SM+TED) | 412.2 ± 4.3**** (SM vs. SM+TED) | 16.5 ± 2.3*** (SM vs. SM+TED) | 16.0 ± 0.9*** (SM vs. SM+TED) | 10.0 ± 0.7ns (SM vs. SM+TED) | 9.0 ± 1.0ns (SM vs. SM+TED) |
| Age-matched Nave control | Both eyes left untreated | 360.0 ± 5.2 | 366.4 ± 4.1 | 11.0 ± 0.4 | 10.3 ± 0.4 | 9.7 ± 0.6 | 9.2 ± 0.5 |
****
P < 0.0001.
***
P = 0.0001.
ns, not significant; data represented in mean ± SEM.