Figure EV2. Irgm2 suppresses caspase‐11 activation in response to pathogenic E. coli infections.

WT, Irgm2 ^−/−, Casp11 ^−/− and Irgm2 ^−/− Casp11 ^−/− BMMs were infected with E. coli K‐12, E. coli UPEC, or E. coli AIEC (MOI 25) and IL‐1β, IL‐18, and LDH release were assessed at 24 hpi. Shown are means ± SEM from n = 3 (IL‐1β, IL‐18) or n = 4 (LDH release) independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 for indicated comparisons by one‐way ANOVA with Tukey's multiple comparisons test.