Figure 6. Irgm2 protects against caspase‐11‐driven septic shock during endotoxemia.

1. WT (n = 9), Irgm2 ^−/− (n = 10), Casp11 ^−/− (n = 7), and Irgm2 ^−/− Casp11 ^−/− (n = 8) mice were injected i.p. with LPS (8 mg/kg). Morbidity and mortality were observed for 48 h at 3‐h intervals.
2. WT (n = 9), Irgm2 ^−/− (n = 8), Casp11 ^−/− (n = 7), and Irgm2 ^−/− Casp11 ^−/− (n = 10) mice were injected i.p. with LPS (8 mg/kg). Serum was collected 4 hpi and concentration of IL‐1β, and IL‐18 was measured by ELISA. Data shown are from 2 pooled experiments.

Data information: Graphs (B) show means ± SEM. *P < 0.05, ***P < 0.001 for indicated comparisons by log‐rank Mantel‐Cox test (A) or one‐way ANOVA with Tukey's multiple comparisons test (B). N.S, non significant.