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. 2020 Oct 9;21(11):e50214. doi: 10.15252/embr.202050214

Figure 4. atgl‐1(xd314) and lid‐1(xd288) show a gentle touch sensation defect.

Figure 4

  1. LDs accumulate in touch neurons in atgl‐1(xd314) visualized by SRS (Stimulated Raman Scattering). The zdIs5 reporter marks touch neurons. The white arrows indicate LDs in touch neurons in atgl‐1(xd314). Scale bar: 10 μm.
  2. atgl‐1(xd314) and lid‐1(xd288) show a gentle touch sensation defect, which is rescued by the neuron‐specific expression of atgl‐1 and lid‐1, respectively. The fat‐4 mutation enhances the touch sensation defect in atgl‐1(xd314) and lid‐1(xd288). Wild type and mec‐4(u253) act as the negative control and positive control, respectively. The data were analyzed using Kruskal–Wallis test with Dunn's test. Asterisks denote significant differences as compared to wild type. ns: not statistically significant. **P < 0.01, ***P < 0.001, ****P < 0.0001. Data show mean ± SEM. # signify significant differences between the groups under the crossbars. ## P < 0.01. Data show mean ± SEM. Number of worms analyzed for each strain n = 25.
  3. The pathway of PUFA synthesis in Caenorhabditis elegans. LA: linoleic acid. ALA: alpha‐linolenic acid. GLA: gamma‐linoleic acid. STA: stearidonic acid. DGLA: dihomo‐gamma‐linolenic acid. ETA: eicosatetraenoic acid. AA: arachidonic acid. EPA: eicosapentaenoic acid. Fatty acids are also indicated by chemical abbreviations. For example, the abbreviation C18:2n−6 means 18 carbons with two double bonds and the first double bond is located at ω−6.