Figure EV2. Genes whose deletion resulted in arginine auxotrophy.

1. Genes encoding mitochondrial proteins identified in our screen were separated to ones that are part of arginine biosynthesis pathway (red), ones that may indirectly impact both respiration and arginine biosynthesis (blue) and others (black). Additionally, cytoplasmic enzymes involved in arginine biosynthesis are indicated. Short descriptions of cellular functions as well as budding yeast and human orthologues of genes indicated in the figure are provided in Table EV1.
2. Gene Ontology (GO) enrichments in the result of the screen identified using threshold‐free GSEA analysis (Subramanian et al, 2005). (We show categories enriched among genes whose deletion results in faster growth with arginine; highlighted in yellow are GO categories containing genes encoding mitochondrial proteins).