Table 1.
Patient characteristics and MRI protocol details.
| Healthy controls | MS patients |
Reliability datasets |
||||
|---|---|---|---|---|---|---|
| Cohorts | Zurich | Dresden | Maclaren | OASIS | Biberacher | |
| sample size | 189 | 94 | 33 | 3 | 20 | 2 |
| healthy | 189 | NA | NA | 3 | 20 | NA |
| MS type at BL (CIS/RRMS/SPMS/PPMS) | NA | 33/54/0/3 | 0/33/0/0 | NA | NA | 0/2/0/0 |
| female | 43 (22%) | 58 (62%) | 20 (60%) | 1 (33%) | 12 (60%) | 2 (100%) |
| age (years) | 53.9 (±10.6) | 34.2 (±8.8) | 38.2 (±10.1) | 26, 31 and 30 | 22 (20–25) | 29 and 24 |
| disease duration (years) | NA | 2.7 (±4.5) | 5.2 (±4.8) | NA | NA | 5 and 5.5 |
| EDSS | NA | 1.3 (±1.3) | 2.7 (±1.6) | NA | NA | 1 and 2 |
| mean no. of scans per patient | 2.4 | 3.5 | 3.9 | 40 | 2 | 5 or 6 |
| mean interval between two consecutive scans | 2.5 years | 1.1 years | 1.1 years | 1 (max 3) days | 11 (3–31) days | 3 (3–4) days |
| mean scan interval first and last scan | 3.5 (±1.9) years | 2.8 (±1.3) years | 3.0 (±0.4) years | 30 days | 11 (3–31) days | 2–3 weeks |
| MRI scanner | 1.5 T Siemens Avanto | 3 T Philips Ingenia | 3 T Siemens Verio | 3 T GE Discovery | 1.5 T Siemens Vision | 3 T GE Signa |
| 3 T Philips Achiva | ||||||
| 3 T Siemens Verio | ||||||
| voxel size in mm | 1 | 0.7 | 1.25 | 1 | 1 | 0.9, 1, 1 |
| slice thickness (mm) | 1 | 0.9 | 1.5 | 1.2 | 1.25 | 1 |
| flip angle (°) | 15 | 8 | 9 | |||
| TR (ms) | 980 | 8.9 | 2000 | 7.3 | 9.7 | 8.2, 9, <9 |
| TE (ms) | 2.95 | 4.07 | 2.8 | 3 | 4 | 3.2, 4, 2.45 |
| TI (ms) | 600 | NA | 900 | 400 | 20 | 450, 1000, 900 |