Table 3. Chart comparison between MSA-P and MSA-C.

MSA-P: Multiple system atrophy – parkinsonism type; MSA-C: multiple system atrophy – cerebellar type.

	MSA-P	MSA-C
Heritability	Sporadic
Progression	Rapid deterioration
Mean survival	9 ± 4 years	8 ± 3 years
Onset	Age 56 ± 10	Definite MSA-C 54.7 ± 8.5 years; possible/probable MSA-C 56.8 ± 8.7 years
Neurogenic orthostatic hypotension	Common in both phenotypes, usually emerges after urogenital symptoms
Urinary incontinence	Common at the time of first evaluation
Clinical characteristics	Mainly rigidity, bradykinesia, postural instability, and/or tremor; anhidrosis more common; more severe, and widespread cognitive dysfunctions	Mainly gait ataxia, limb ataxia, dysarthria, and/or nystagmus; anhidrosis less common; less severe visuospatial and constructional dysfunctions
MRI findings	Hypointensity of the posterior putamen, hot cross bun sign, hyperintense T2 signal in the shape of a cross within the pons it is produced from degeneration of transverse pontocerebellar fibers (both MSA-C and MSA-P)	More frequent abnormalities, especially cerebellar/pons atrophy, hyperintensities of the middle cerebellar peduncles, hot cross bun sign, hyperintense T2 signal in the shape of a cross within the pons it is produced from degeneration of transverse pontocerebellar fiber (both MSA-C and MSA-P)