Table 3.
Summary of PLCE1 rs2274223 and its association with risk of LSCC
| Model | Genotype | Controls | Cases | OR (95% CI) | P value |
|---|---|---|---|---|---|
| A/A | 216 (61.9%) | 178 (53.8%) | 1.00 | ||
| A/G | 125 (35.8%) | 135 (40.8%) | 1.28 (0.92-1.79) | 0.146 | |
| G/G | 8 (2.3%) | 18 (5.4%) | 2.82 (1.13-7.06) | 0.026 | |
| Dominant | A/A | 216 (61.9%) | 178 (53.8%) | 1.00 | 0.056 |
| A/G-G/G | 133 (38.1%) | 153 (46.2%) | 1.37 (0.99-1.90) | ||
| Recessive | A/A-A/G | 341 (97.7%) | 313 (94.6%) | 1.00 | 0.035 |
| G/G | 8 (2.3%) | 18 (5.4%) | 2.56 (1.03-6.34) | ||
| Overdominant | A/A-G/G | 224 (64.2%) | 196 (59.2%) | 1.00 | 0.260 |
| A/G | 125 (35.8%) | 135 (40.8%) | 1.21 (0.87-1.68) | ||
| Log-additive | --- | --- | --- | 1.40 (1.06-1.86) | 0.019 |
OR, odds ratio; CI, confidence interval. P values are two sided and were calculated in logistic regression analysis adjusted for sex, age, smoking status and drinking status. Significant results were in bold.