Table 4.
Summary of stratified analysis of associations between rs2274223 and LSCC risk in additive model
| MAF Cases | MAF Controls | OR (95% CI) | P value* | Interaction P value | |
|---|---|---|---|---|---|
| Age, years | |||||
| > 60 | 0.271 | 0.197 | 1.50 (1.05-2.15) | 0.027 | 0.677 |
| ≤ 60 | 0.245 | 0.214 | 1.23 (0.75-2.00) | 0.408 | |
| Gender | |||||
| Male | 0.255 | 0.197 | 1.39 (1.03-1.86) | 0.030 | 0.798 |
| Female | 0.304 | 0.231 | 1.80 (0.56-5.80) | 0.323 | |
| Smoking status | |||||
| Smoker | 0.254 | 0.208 | 1.31 (0.94-1.82) | 0.110 | 0.483 |
| Nonsmoker | 0.283 | 0.193 | 2.00 (1.09-3.69) | 0.026 | |
| Drinking status | |||||
| Drinker | 0.268 | 0.208 | 1.45 (0.99-2.14) | 0.057 | 0.945 |
| Nondrinker | 0.239 | 0.197 | 1.38 (0.89-2.15) | 0.153 |
MAF, minor allele frequency; OR, odds ratio; CI, confidence interval. *P values are two sided and were calculated in logistic regression analysis adjusted for sex, age, smoking status and drinking status. The interaction P values were calculated by conducting a one degree-of-freedom Wald test of a single interaction parameter as implemented in an unconditional logistic regression with age, sex, smoking status or drinking status as covariates.