Table 3.
Univariate and multivariate Cox regression for prognostic factors in patients with AP in MIMIC-III database
| Unadjusted HR (95%CI) | P | Adjusted HR (95%CI) | P | |
|---|---|---|---|---|
| Age, year | 1.034 (1.020-1.049) | <0.001 | 1.047 (1.024-1.071) | <0.001 |
| Sex, male, n (%) | 1.061 (0.693-1.625) | 0.784 | ||
| Ethnicity, n (%) | ||||
| White | 0.448 (0.289-0.695) | <0.001 | 0.358 (0.185-1.069) | 0.092 |
| Black | 0.347 (0.134-0.899) | 0.029 | 0.374 (0.100-1.283) | 0.115 |
| Others | Ref. | - | - | - |
| BMI, kg/m2 | 1.000 (0.972-1.030) | 0.985 | ||
| Comorbidities, n (%) | ||||
| Chronic kidney disease | 1.080 (0.608-1.919) | 0.792 | ||
| Hypertension | 1.239 (0.815-1.885) | 0.315 | ||
| Diabetes | 1.366 (0.869-2.149) | 0.176 | ||
| Chronic heart failure | 1.863 (1.197-2.866) | 0.006 | 1.874 (0.945-3.719) | 0.072 |
| Complication, n (%) | ||||
| Acute kidney injury | 1.906 (1.087-3.342) | 0.024 | 1.197 (0.517-2.773) | 0.674 |
| Sepsis | 2.254 (1.435-3.541) | <0.001 | 1.648 (0.847-3.207) | 0.141 |
| Therapeutic management, n (%) | ||||
| Vasopressor usage | 3.017 (1.848-4.927) | <0.001 | 1.791 (0.767-3.181) | 0.178 |
| Mechanical ventilation | 1.539 (0.920-2.574) | 0.101 | ||
| Renal replacement therapy | 1.817 (1.156-2.855) | 0.010 | 1.493 (0.718-3.105) | 0.283 |
| Clinical management, n (%) | ||||
| Endoscopic necrectomy | 0.433 (0.004-28.457) | 0.344 | ||
| Surgical necrectomy | 1.143 (0.356-3.665) | 0.823 | ||
| ERCP | 0.813 (0.485-1.365) | 0.434 | ||
| Severity of illness, points | ||||
| SOFA score | 1.140 (1.085-1.198) | <0.001 | 1.222 (1.110-1.346) | <0.001 |
| OASIS score | 1.049 (1.026-1.071) | <0.001 | 0.961 (0.919-1.006) | 0.086 |
| Biochemical data | ||||
| MAP, mmHg | 0.986 (0.973-0.999) | 0.038 | 1.004 (0.984-1.026) | 0.675 |
| Leucocyte,×109/L | 1.022 (1.008-1.037) | 0.003 | 1.035 (1.013-1.058) | 0.002 |
| Hemoglobin, g/dL | 1.038 (0.931-1.158) | 0.502 | ||
| Platelet, ×109/L | 0.972 (0.584-1.144) | 0.240 | ||
| Serum albumin, g/L | 0.916 (0.905-0.968) | <0.001 | 0.962 (0.927-0.998) | 0.037 |
| Total bilirubin, mg/dL | 0.761 (0.651-0.890) | 0.001 | 0.768 (0.635-0.928) | 0.006 |
| Direct bilirubin, mg/dL | 1.091 (1.049-1.134) | <0.001 | 1.002 (0.966-1.038) | 0.927 |
| Lactate, mmol/L | 1.134 (1.073-1.198) | <0.001 | 1.075 (0.985-1.173) | 0.104 |
| Lipase, IU/L | 1.000 (0.998-1.001) | 0.174 | ||
| Amylase, IU/L | 1.001 (0.999-1.002) | 0.950 | ||
| Urea nitrogen, mg/dL | 1.014 (1.007-1.020) | <0.001 | 1.001 (0.989-1.012) | 0.887 |
| Serum creatinine, mg/dL | 1.144 (1.033-1.267) | <0.001 | 0.972 (0.738-1.281) | 0.842 |
| Alkaline phosphatase, IU/L | 1.002 (0.998-1.002) | 0.751 | ||
| SAP | 1.878 (1.235-2.856) | 0.003 | 1.097 (0.496-2.428) | 0.819 |
HR, hazard ratio; 95%CI, 95% confidence interval; ERCP, edoscopic retrograde cholangiopancreatography; SOFA, sequential organ failure assessment, OASIS, oxford acute severity of illness score; MAP, mean arterial pressure; DBIL, direct bilirubin; SAP, severe acute pancreatitis.