Table 4.

Comparison of the performances of four serum autoantibodies in diagnosing the patients with CC at early stage

Marker	Sensitivity (%)	Specificity (%)	AUC	SE	95% CI	P
p53-IgG	23.6	96.7	0.644	0.032	0.594-0.692	<0.001
HRAS-IgG	18.5	97.0	0.631	0.031	0.580-0.679	<0.001
NSG1-IgG	20.4	95.3	0.649	0.030	0.599-0.697	<0.001
TIF1γ-IgA	25.5	96.7	0.716	0.027	0.668-0.761	<0.001
p53, HRAS-IgG	34.4	94.0	0.680	0.031	0.630-0.726	<0.001
p53, NSG1-IgG	38.2	92.0	0.688	0.031	0.639-0.734	<0.001
p53-IgG +TIF1γ-IgA	40.8	93.7	0.728	0.029	0.680-0.772	<0.001
HRAS, NSG1-IgG	30.6	93.0	0.664	0.031	0.614-0.711	<0.001
HRAS-IgG+TIF1γ-IgA	35.7	95.3	0.724	0.028	0.676-0.769	<0.001
NSG1-IgG+TIF1γ-IgA	35.7	92.7	0.710	0.028	0.662-0.755	<0.0001
p53, HRAS, NSG1-IgG	44.6	90.0	0.695	0.031	0.646-0.741	<0.001
p53, HRAS-IgG+TIF1γ-IgA	47.1	92.0	0.737**	0.029	0.690-0.781	<0.001
p53, NSG1-IgG+TIF1γ-IgA	46.5	89.7	0.727	0.029	0.680-0.771	<0.001
HRAS, NSG1-IgG+TIF1γ-IgA	42.0	91.3	0.722	0.029	0.675-0.767	<0.001
p53, HRAS, NSG1-IgG+TIF1γ-IgA	51.6	88.0	0.735	0.029	0.688-0.779	<0.001

Notes: ** indicate the highest AUC among all possible combinations of four autoantibodies;

Abbreviations: AUC, area under the curve; SE, standar error; CI, confidence interval.