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. 2019 Dec 26;48(4):0300060519893234. doi: 10.1177/0300060519893234

Table 4.

Top 20 cited articles on CHB treatment.

Title Author Journal Year Total Cited
Lamivudine as initial treatment for chronic hepatitis B in the United States21 Dienstag JL, Schiff ER, Wright TL, et al. New England Journal of Medicine 1999 1105
Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B22 Marcellin P, Chang T, Lim SG, et al. New England Journal of Medicine 2003 1057
Effect of alpha-interferon treatment in patients with hepatitis-B e-antigen-positive chronic hepatitis-B – a meta analysis23 Wong DKH, Cheung AM, Orourke K, et al. Annals of Internal Medicine 1993 865
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B24 Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. New England Journal of Medicine 2003 763
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years25 Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Gastroenterology 2006 685
A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B26 Perrillo RP, Schiff ER, Davis GL, et al. New England journal of Medicine 1990 684
Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study27 Marcellin P, Gane E, Buti M, et al. Lancet 2013 682
Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B28 Niederau C, Heintges T, Lange S, et al. New England Journal of Medicine 1996 670
Long-term safety of lamivudine treatment in patients with chronic hepatitis B29 Lok ASF, Lai CL, Leung N, et al. Gastroenterology 2003 621
Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B30 Liaw YF, Leung NWY, Chang TT, et al. Gastroenterology 2000 620
Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy31 Werle-Lapostolle B, Bowden S, Locarnini S, et al. Gastroenterology 2004 602
AASLD guidelines for treatment of chronic hepatitis B32 Terrault NA, Bzowej N H, Chang K-M, et al. Hepatology 2016 597
Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapy33 Leung NWY, Lai CL, Chang TT, et al. Hepatology 2001 542
Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B34 Chang TT, Liaw YF, Wu SS, et al. Hepatology 2010 541
Prevalence and clinical correlates of YMDD variants during lamivudine therapy for patients with chronic hepatitis B35 Lai CL, Dienstag J, Schiff E, et al. Clinical Infectious Diseases 2003 518
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B36 Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. New England Journal of Medicine 2005 453
Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial37 Schalm SW, Heathcote J, Cianciara J, et al. Gut 2000 427
Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B38 Boni C, Bertoletti A, Penna A, et al. Journal of Clinical Investigation 1998 380
A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update39 Keeffe EB, Dieterich DT, Han S-H, et al. Clinical Gastroenterology and Hepatology 2008 376
Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B40 Villeneuve JP, Condreay LD, Willems B, et al. Hepatology 2000 374

CHB, chronic hepatitis B.