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. 2020 Sep 24;12(11):e12619. doi: 10.15252/emmm.202012619

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© 2020 The Authors. Published under the terms of the CC BY 4.0 license

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Figure EV2 — Coomassie stain (left panel) and an in‐gel complex I assay (right panel) in BN‐PAGE showed a reduction of complex I‐containing supercomplexes in subject mitochondria. Analysis of complex assembly and stability detected a drastic deficiency of complex I‐containing supercomplexes.

S₁, supercomplex containing complex I, dimer of complex III and 1 copy of complex IV; V, ATP synthase; I‐III‐IV, complexes I‐III‐IV. BHM, bovine heart mitochondria solubilised with digitonin as native mass ladder.