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. 2020 Nov 5;10:19201. doi: 10.1038/s41598-020-76062-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacological responses of HMDs to isoproterenol. (a) Dose-dependent change in the beating rate of HMDs. Bpm, beats per minute; Iso, isoproterenol. (b) Representative changes in the particle position in accordance with the administration of isoproterenol. Left: no treatment; Right, administration of isoproterenol (10^–8 M). (c) Representative relationship between the beating rate of the HMD (X) and the particle displacement distance in the whole beating cycle (Y). The results of the regression analysis are shown. All data are shown in Supplementary Fig. 4.