Table 2.
Comparison between patients with severe and mild-moderate headache at ER (n = 97).
| Severe headache (n = 24) |
Mild-moderate headache (n = 73) |
Adjusted p-valuea |
|
|---|---|---|---|
| Demographic characteristics | |||
| Age (years), mean ± SD | 44.8 ± 14.9 | 52.5 ± 15.1 | 0.049* |
| Sex (female), n (%) | 20 (83.3) | 36 (49.3) | 0.004** |
| History of any type of headache, n (%) | 10 (41.7) | 21 (28.8) | 0.313 |
| History of migraine, n (%) | 6 (25.0) | 13 (17.8) | 0.554 |
| Headache characteristics | |||
| Onset before another COVID-19 symptom, n (%) | 6 (25.0) | 3 (4.1) | 0.007** |
| Time since headache onset to ER presentation (days), median (IQR) | 10.5 (10.0) | 6.0 (6.0) | 0.002** |
| Holocraneal pain, n (%) | 9 (37.5) | 28 (38.4) | 1.000 |
| Pain quality, n (%) | |||
| Pressing | 11 (45.8) | 57 (78.1) | 0.004** |
| Throbbing | 9 (37.5) | 10 (13.7) | 0.017* |
| Other migraine features, n (%) | |||
| Worsening with movement | 6 (25.0) | 6 (8.2) | 0.066 |
| Nausea and vomiting | 11 (45.8) | 14 (19.2) | 0.015* |
| Photo/phonophobia | 5 (20.8) | 5 (6.8) | 0.114 |
| Daily constant pain, n (%) | 18 (75.0) | 30 (41.1) | 0.005** |
| Response to acute treatment, n (%) | 9 (37.5) | 48 (65.8) | 0.018* |
aAdjusted p-value with Benjamini-Hochberg procedure.
*p-value ≤0.05.
**p-value ≤0.01.
ER: Emergency room; SD: standard deviation; IQR: interquartile range.