Table 2.

Results from the best fitting models for Mendelian randomization

Exposure phenotype	Outcome phenotype	Number of SNPs	Model	Beta	SE	P-value
CH	IOPcc	144	IVW	−0.128	0.024	<1E-3
			Egger	0.048	0.065	0.462
			Egger intercept	−0.011	0.004	0.014
CRF	IOPcc	166	IVW	0.31	0.021	<1E-3
			Egger	0.005	0.054	0.928
			Egger intercept	0.018	0.004	<1E-3
IOPcc	CH	99	IVW	−0.154	0.009	<1E-3
			Egger	−0.153	0.032	<1E-3
			Egger intercept	0.002	0.004	0.537
IOPcc	CRF	96	IVW	0.137	0.01	<1E-3
			Egger	0.12	0.031	<1E-3
			Egger intercept	0.002	0.004	0.54

For the model, IVW is the penalized inverse weighted variance, Egger is the penalized Egger model and Egger intercept is the corresponding intercept results for the given Egger results shown. Number of SNPs is the number of uncorrelated SNPs used as genetic instruments for each test.