Table 4.
Apical end-points related to ethinyl estradiol exposure.
| Barcode | Exp_ID | Group_ID | Individual_ID | Compound_name | Dose_level | Sacrifice_period | Finding_type | Topography_type | |
|---|---|---|---|---|---|---|---|---|---|
| 3.02E+09 | 305 | 10 | 3 | Ethinylestradiol | Middle | 8 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 14 | 2 | Ethinylestradiol | High | 8 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 14 | 4 | Ethinylestradiol | High | 8 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 14 | 1 | Ethinylestradiol | High | 8 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 14 | 5 | Ethinylestradiol | High | 8 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 12 | 2 | Ethinylestradiol | Middle | 29 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 12 | 3 | Ethinylestradiol | Middle | 29 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 16 | 2 | Ethinylestradiol | High | 29 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 16 | 4 | Ethinylestradiol | High | 29 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 16 | 5 | Ethinylestradiol | High | 29 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 12 | 1 | Ethinylestradiol | Middle | 29 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 12 | 5 | Ethinylestradiol | Middle | 29 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 16 | 1 | Ethinylestradiol | High | 29 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 16 | 3 | Ethinylestradiol | High | 29 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 11 | 5 | Ethinylestradiol | Middle | 15 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 15 | 2 | Ethinylestradiol | High | 15 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 15 | 3 | Ethinylestradiol | High | 15 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 15 | 5 | Ethinylestradiol | High | 15 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 11 | 1 | Ethinylestradiol | Middle | 15 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 11 | 3 | Ethinylestradiol | Middle | 15 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 15 | 1 | Ethinylestradiol | High | 15 day | Change, eosinophilic | Periportal | |
| No ChipData | 305 | 15 | 4 | Ethinylestradiol | High | 15 day | Change, eosinophilic | Periportal | |
| 3.02E+09 | 305 | 16 | 2 | Ethinylestradiol | High | 29 day | Dilatation | Sinusoid | |
| No ChipData | 305 | 16 | 1 | Ethinylestradiol | High | 29 day | Dilatation | Sinusoid | |
| No ChipData | 305 | 16 | 3 | Ethinylestradiol | High | 29 day | Dilatation | Sinusoid | |
| 3.02E+09 | 305 | 12 | 3 | Ethinylestradiol | Middle | 29 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 16 | 2 | Ethinylestradiol | High | 29 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 16 | 4 | Ethinylestradiol | High | 29 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 16 | 5 | Ethinylestradiol | High | 29 day | Hypertrophy | Centrilobular | |
| No ChipData | 305 | 12 | 5 | Ethinylestradiol | Middle | 29 day | Hypertrophy | Centrilobular | |
| No ChipData | 305 | 16 | 1 | Ethinylestradiol | High | 29 day | Hypertrophy | Centrilobular | |
| No ChipData | 305 | 16 | 3 | Ethinylestradiol | High | 29 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 15 | 2 | Ethinylestradiol | High | 15 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 15 | 5 | Ethinylestradiol | High | 15 day | Hypertrophy | Centrilobular | |
| 3.02E+09 | 305 | 2 | 5 | Ethinylestradiol | Control | 8 day | Necrosis | Hepatocyte | |
| 3.02E+09 | 305 | 10 | 3 | Ethinylestradiol | Middle | 8 day | Necrosis | Hepatocyte | |
| 3.02E+09 | 305 | 14 | 3 | Ethinylestradiol | High | 8 day | Necrosis | Hepatocyte | |
| 3.02E+09 | 305 | 9 | 2 | Ethinylestradiol | Middle | 4 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 5 | 3 | Ethinylestradiol | Low | 4 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 9 | 4 | Ethinylestradiol | Middle | 4 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 13 | 5 | Ethinylestradiol | High | 4 day | Necrosis | Hepatocyte | |
| 3.02E+09 | 305 | 8 | 4 | Ethinylestradiol | Low | 29 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 8 | 3 | Ethinylestradiol | Low | 29 day | Necrosis | Hepatocyte | |
| 3.02E+09 | 305 | 7 | 4 | Ethinylestradiol | Low | 15 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 3 | 3 | Ethinylestradiol | Control | 15 day | Necrosis | Hepatocyte | |
| No ChipData | 305 | 13 | 5 | Ethinylestradiol | High | 4 day | Proliferation, Kupffer cell | ||
| 3.02E+09 | 305 | 16 | 2 | Ethinylestradiol | High | 29 day | Proliferation, Kupffer cell | ||
| 3.02E+09 | 305 | 16 | 4 | Ethinylestradiol | High | 29 day | Proliferation, Kupffer cell | ||
| No ChipData | 305 | 16 | 3 | Ethinylestradiol | High | 29 day | Proliferation, Kupffer cell | ||
| 3.02E+09 | 305 | 15 | 3 | Ethinylestradiol | High | 15 day | Proliferation, Kupffer cell | ||
| No ChipData | 305 | 15 | 1 | Ethinylestradiol | High | 15 day | Proliferation, Kupffer cell | ||
| No ChipData | 305 | 13 | 5 | Ethinylestradiol | High | 4 day | Single cell necrosis | Hepatocyte | |
| No ChipData | 305 | 16 | 3 | Ethinylestradiol | High | 29 day | Single cell necrosis | Hepatocyte | |