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. 2020 Nov 5;10:19220. doi: 10.1038/s41598-020-76070-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Catwalk gait analysis of female wild-type and TDP-43^Q331K/Q331K mice shows gait deficits in aged mutants. (a) Hindlimb base of support (BOS) (P < 0.05; two-way ANOVA). (b) Hindlimb swing time (P < 0.0001; two-way ANOVA). (c) Hindlimb swing speed (P < 0.05; two-way ANOVA). (d) Percentage of diagonal walking (P < 0.05; two-way ANOVA). (e) Percentage of 3-paw walking (P < 0.01; two-way ANOVA). (f) Percentage of 4-paw walking (P < 0.05 at 20 months on multiple comparisons; two-way ANOVA). All data is from 8 to 20 months of age (n = 10 per genotype (8 months); 10 wild-type, 9 mutants (10 and 12 months); 9 per genotype (14 months); 9 wild-type, 7 mutants (20 months)). Error bars represent mean ± s.e.m. *P < 0.05, **P < 0.01, ****P < 0.0001.