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. 2020 Nov 5;10:19097. doi: 10.1038/s41598-020-76200-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of mechanism-induced subtypes in AD and PD: (A) Consensus clustering of ADNI AD patients (consensus matrix). (B) Consensus clustering of PPMI PD patients (consensus matrix). (C) Consensus clustering of merged ADNI + PPMI (consensus matrix). (D) Consensus clustering of merged validation data (integrated AETIONOMY AD + PD, consensus matrix). (E) Prediction performance of a classifier that allows assigning each patient in a validation cohort to a cluster in the discovery cohort. (F) Coherence of joint AD + PD clustering with validation cohort: Shown is the in-group proportion measure and its p-value according to a permutation test.