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. 2020 Nov 5;10:19097. doi: 10.1038/s41598-020-76200-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Example of significant differences between clusters with respect to brain imaging derived features at study baseline/time of first disease diagnosis (see “Methods” section). (A) left calcarine sulcus in AD patients; (B) left cuneus gyrus in AD patients; (C) volume of right medial occipitotemporal gyrus in AD patients; (D) DaTSCAN left Putamen—ratio to age expected value in healthy controls; (E) DaTSCAN Count Density Ratio: Caudate/Putamen; (F) DaTSCAN Count Density Ratio (CL): Caudate contralateral/Putamen contralateral. The Figures shows statistical distributions as violin plots (i.e. boxplots plus kernel density estimates), and individual data points are shown as superimposed dots.