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. 2020 Nov 5;10:19118. doi: 10.1038/s41598-020-75933-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DNA microarray analysis of HUVEC genes involved in invasion by S. mutans. (A) Venn diagram showing the selection of genes by their differential expression (> 2.0-fold difference) in the indicated infected cells. A total of 82 genes were significantly upregulated both in TW295-infected HUVECs compared with TW295CND-infected HUVECs and in TW295-infected HUVECs compared with uninfected HUVECs but were not differentially expressed in TW295CND-infected HUVECs compared with uninfected HUVECs. (B) Three of the 82 differentially expressed genes were identified as regulators of small G proteins. Microarray data was analyzed using Agilent Feature Extraction (Agilent Technologies, Santa Clara, CA, USA).