Table 1.
Histopathological evaluation of extirpated heart tissues from IE model rats.
| Histopathological finding | MT8148 (n = 6) | TW295 (n = 6) | TW295CND (n = 6) | TW295comp (n = 6) | No infection (n = 6) |
|---|---|---|---|---|---|
| Infiltration of inflammatory cells | 1.17 ± 0.28** | 1.83 ± 0.40** | 0.17 ± 0.17# | 2.17 ± 0.40** | 0.17 ± 0.17## |
| Hypertrophy of the endocardium | 0.75 ± 0.11## | 1.83 ± 0.31* | 0.33 ± 0.21# | 0.50 ± 0.34## | 0.33 ± 0.33# |
| Hypertrophy of the annulus | 1.08 ± 0.42 | 1.33 ± 0.49 | 0.00 ± 0.00# | 0.17 ± 0.17 | 0.33 ± 0.33 |
| Acceleration of fibrosis | 1.25 ± 0.34 | 1.50 ± 0.41* | 0.00 ± 0.00# | 1.67 ± 0.33** | 0.17 ± 0.17# |
| Fibrin-like deposition | 1.00 ± 0.34 | 1.58 ± 0.27* | 0.08 ± 0.08## | 1.00 ± 0.52 | 0.33 ± 0.33# |
| Bacterial mass | 0.08 ± 0.08# | 1.33 ± 0.42* | 0.00 ± 0.00# | 0.17 ± 0.17# | 0.00 ± 0.00# |
Values in each column indicate mean ± standard error. There were significant differences between no infection (*P < 0.05, **P < 0.01) and TW295 groups (#P < 0.05, ##P < 0.01).