Figure 4.

Relationships between dopamine synthesis capacity (Ki^cer) and psychotic symptoms. (A) Associations between Positive and Negative Syndrome Scale Marder factors and striatal Ki^cer (Ki) across different striatal subdivision regions. Heatmap displays r_p values. Statistical significance calculated by permuting participants. ∗p < .05, ∗∗p < .05 (false discovery rate corrected). (B) The strongest association observed using the connectivity-based approach was between default mode network (DMN)–Ki^cer and the Marder negative factor score (r_p = .49, p = .009). (C) Heatmaps illustrating the extent to which symptom-Ki^cer associations differ between subdivisions. Positive values indicate that the row subdivision shows a greater association with the Marder factor than the column subdivision. ∗p < .05. Connectivity-defined subdivisions: auditory network (AUD), cingulo-opercular network (CON), dorsal attention network (DAT), DMN, and sensorimotor network (SMN). Anatomically defined subdivisions: whole striatum (WST), associative striatum (WST), limbic striatum (LST), and sensorimotor striatum (SMST).