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. 2020 Nov 3;19:1533033820956987. doi: 10.1177/1533033820956987

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Silencing BRAF inhibited the proliferation, migration and invasion of choroidal melanoma cells. A and B, Western blot analysis revealed that the expression of BRAF protein was remarkably downregulated by transfecting si-BRAF-1 and si-BRAF-2. ****P < 0.0001, **P < 0.01. C, D and E, Compared to the NC group, silencing BRAF by 2 siRNAs inhibited cell proliferation. ****P < 0.0001, ***P < 0.001, **P < 0.01. F, G and H, After silencing BRAF by 2 siRNAs, the numbers of migrating and invading cells were noticeably decreased. ****P < 0.0001, ***P < 0.001. (si-NC, siRNA negative control).