TABLE 1.
Clinical and neuropathologic findings of 50 COVID‐19 postmortem cases
| Observation | Number of cases | Reference |
|---|---|---|
| Sex | ||
| Male | 24 | (1, 2, 3, 4, 5, 6) |
| Female | 8 | 1, 3, 4, 6) |
| t reported | 18 | (1) |
| Age | ||
| <21 | 0 | |
| 21–49 | 1 | (6) |
| 50–64 | 5 | (3, 6) |
| >65 | 7 | (2, 3 ,5, 6) |
| Not reported | 37 | (1, 4) |
| Serum cytokine and procoagulant levels | ||
| Elevated | 21 | (1, 2) |
| Normal | 0 | |
| Not reported | 29 | (3, 4, 5, 6) |
| Duration of hospital illness to death (days) | ||
| 0–1 | 5 | (4, 5, 6) |
| –10 | 18 | (2, 3, 4, 6) |
| >10 | 9 | (3, 4, 6) |
| Not reported | 18 | (1) |
| Cause of death | ||
| Massive intracranial hemorrhage | 2 | (3) |
| Cerebellar hemorrhage and herniation | 1 | (5) |
| Pulmonary embolism | 2 | (3, 6) |
| Cardiopulmonary failure | 5 | (3, 6) |
| Multisystem organ failure | 1 | (2) |
| Not reported | 39 | (1, 4, 6) |
| SARS‐CoV‐2 reactivity in brain sections | ||
| Positive | 0 | |
| Negative | 24 | (2, 3, 5, 6) |
| Not Reported | 26 | (1, 4) |
| Neuropathology | ||
| Acute microscopic thrombotic ischemic infarcts | 4 | (1) |
| Acute microscopic hemorrhagic infarcts | 2 | (1, 2) |
| Petechial hemorrhage | 3 | (3) |
| Focal perivascular parenchymal T‐cell infiltrates | 3 | (1, 2, 5) |
| Diffuse perivascular parenchymal T‐cell infiltrates | 2 | (2, 5) |
| Leptomeningeal inflammation | 7 | (3, 4) |
| Interstitial brainstem inflammation with neuronal loss | 6 | (3) |
| Capillary endothelium expression of ACE2 receptor | 1 | (2) |
| Microglial nodules | 1 | (5) |
| Hypoxic ischemia changes and neuronal loss | 25 | (1, 4, 5, 6) |
| Associated findings | ||
| Chronic infarction | 3 | (4) |
| Alzheimer disease | 5 | (3, 4) |
| Lewy body disease | 2 | (4) |
| Primary brain tumor | 1 | (4) |