Separation of severe/critical from mild/moderate cases in adult patients with no comorbidities. The scores scatter plot for partial least squares regression discriminant analysis to separate severe/critical from mild/moderate cases (A). PLS‐DA loadings for components ascertained influencing biomarkers (B). The severe/critical cases had a higher LDH (C) and prealbumin (D) levels at admission compared with mild/moderate cases. Dynamic curves of LDH and prealbumin in individual patients with major events during the progression (E). LDH, lactate dehydrogenase; PA, prealbumin; AST, aspartate aminotransferase; APTT, activated partial thromboplastin time; ALB, albumin; PT, prothrombin time; CRP, c‐reactive protein; DD, d‐dimer; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; GGT, γ‐glutamyl transpeptidase; WBC, white blood cell count; NEUT, neutrophils; LYM, lymphocytes; HGB, hemoglobin; PLT, platelets; Bun: blood urea nitrogen; CREA, creatinine; UA, uric acid; CK, creatine kinase