Skip to main content
. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: J Thromb Haemost. 2020 Mar 30;18(6):1278–1290. doi: 10.1111/jth.14785

Figure 3. PEGylation of A1A2A3-VWF modulates VWF clearance in a site-specific manner.

Figure 3.

Following site-specific PEGylation, the clearance of A1A2A3-VWF variants were assessed in VWF−/− mice. (A) The clearance of A1-domain variants, (B) A2-domain variants and (C) A3-domain variants were all compared to non-PEGylated A1A2A3-WT. (D) PEGylation served to markedly increase the MRT of A1A2A3-VWF in a site-dependent manner. All data is graphed as mean values ± SEM, 3-5 mice per time point (* p <0.05, ** p <0.01, *** p <0.0001 respectively).