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. 2020 Oct 23;16(16):3221–3230. doi: 10.7150/ijbs.49410

Figure 1.

Figure 1

GRB7 is upregulated in bladder cancer. A. The mRNA level of TEF was frequently upregulated in bladder cancer tissues (Tumor) compared to that in normal bladder epithelial samples (Normal) in the TCGA database. Values are expressed as the mean ± SEM. **P < 0.001. B. The RNA levels of TEF were markedly decreased in 18 paired bladder cancer tissues (Tumor) compared to those in adjacent normal tissues (Normal) from 18 patients in the TCGA database. **P < 0.001. C. RT-qPCR analysis showed that the mRNA level of GRB7 was indeed upregulated in all of the seven cultured bladder cell lines compared to that in normal epithelial cells (Normal). D. GRB7 protein was also higher in the seven cultured bladder cell lines compared to that in normal epithelial cells. E. RT-qPCR analysis showed that the mRNA level of GRB7 were upregulated in malignant bladder cancer tissues (Tumor) compared to that in adjacent normal tissues. *P < 0.05. F. Western blot analysis revealed that the protein level of GRB7 were upregulated in malignant bladder cancer tissues compared to that in adjacent normal tissues.