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. 2020 Oct 23;16(16):3221–3230. doi: 10.7150/ijbs.49410

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Phospho-AKT pathway mediates GRB7-induced cell proliferation and tumorigenesis. A. MTT assays showed that AKT inhibitor could significantly restore GRB7-promoted growth rate. B. The representative images of colonies in soft agar assays visually indicating that AKT inhibitors can weaken GRB7-induced tumorigenicity. C. Numbers of colonies in the anchorage-independent growth assay. D. Flow cytometry analysis showed that perifosine significantly abrogated the GRB7-induced enrichment of cells in the S phase. E. Quantification of BrdU incorporation in the constructed stable cell lines. *P < 0.05.