Table 1.
Microbiota-state time series
| DSS | rat | T-7 | T-1 | T3 | T13 | T17 | T27 | T31 | T40 | T63 | T68/75 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 48 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 2 | 1 | 1A |
| 0.25 | 26 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1A |
| 0 | 17 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1A |
| 0.25 | 21 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1A |
| 0 | 13 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1A |
| 0 | 19 | 1 | 1 | 1 | 1 | 1 | nd | nd | 1 | 1 | 1A |
| 0.25 | 30 | 1 | 1 | 1 | 2 | 1 | 1 | nd | 1 | 1 | 1A |
| 2 | 56 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 1 | 50 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 1 | 49 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 1 | 45 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 0.5 | 40 | 2 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 0.5 | 39 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 0 | 14 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1A |
| 3 | 11 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1A |
| 0.25 | 28 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0 | 12 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.5 | 34 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 2 | 53 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 1 | 46 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 1 | 44 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.5 | 38 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.5 | 37 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.5 | 36 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.5 | 31 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.25 | 29 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.25 | 23 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0.25 | 22 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0 | 16 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0 | 15 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1A |
| 0 | 20 | 1 | 1 | 1 | 1 | 1 | 2 | nd | 2 | 2 | 1B |
| 2 | 58 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 1B |
| 2 | 60 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 1B |
| 2 | 54 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1B |
| 0.5 | 33 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1B |
| 3 | 65 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1B |
| 3 | 43 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1B |
| 1 | 42 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1B |
| 1 | 41 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1B |
| 3 | 70 | 1 | 1 | 1 | 1 | 1 | 2 | nd | 2 | 2 | 2A |
| 0 | 18 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2A |
| 0.5 | 35 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 2 | 2A |
| 2 | 57 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2A |
| 2 | 59 | 2 | 1 | 1 | 1 | 1 | 1 | nd | 1 | 1 | 2A |
| 0.5 | 32 | 1 | 1 | 1 | 1 | nd | 2 | 2 | 1 | 1 | 2A |
| 0.25 | 27 | 2 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 2A |
| 0.25 | 25 | 1 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 2A |
| 0.25 | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2A |
| 3 | 64 | 1 | 1 | 1 | 1 | 1 | nd | 2 | 2 | 2 | 2B |
| 3 | 68 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2B |
| 2 | 52 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2B |
| 2 | 51 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2B |
| 3 | 62 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 1 | 2 | 2B |
| 3 | 69 | 1 | 1 | 1 | 1 | 1 | 1 | nd | 2 | 1 | 2B |
| 3 | 67 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 2B |
| 2 | 55 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 1 | 2B |
| 1 | 47 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 2B |
| 3 | 66 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2B |
Evolution of microbiota state with time is indicated for individual rats. DSS percentage of DSS used during treatment periods, rat rat number; T-7 to T63, time-points of fecal sampling; T68/75, T68 for fecal sampling and T75 for distal colon inflammatory status evaluation, respectively; 1 basal-state microbiota, 2 (bold script), alternative-state microbiota, nd not determined, A basal host inflammatory state, B alternative host inflammatory state (low-level inflammation). Rats (lines of the table) are grouped according to the host-ecosystem state at T68/75 (last column, cf Fig. 5), then by resemblance of microbiota-by-time profile from T27 onward