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. 2020 Nov 6;18:163. doi: 10.1186/s12915-020-00893-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4. — Associations between levels of Serpin E1, IL-8, MIF, and PDGF-AA and survival in breast cancer patients. The METABRIC dataset was used to assess the association between expression levels of Serpin E1 (a), IL-8 (b), PDGF-AA (c), MIF (d) and the mean signature levels of all 4 factors (median of the mean of normalized expression levels of the four factors) (e), with 10-year survival. Protein levels were classified as higher or lower than the median, and the association to 10-year survival was assessed by the Kaplan-Meier analysis (n = 952 per group). p value was calculated using two-sided log rank test