Figure 5.

Panorama overview of clinically applied TCM remedies in relationship to medical conditions based on molecular target analysis. (A) SSMs (symptoms, syndromes and medical conditions) involved in COVID-19 constrained with the TCMSP database. Fourteen SSMs related to COVID-19 throughout the whole course are shown on the X axis, while the percent constrained with the TCMSP entire database is shown on the Y axis. Incorporated targets are orange, and blue reflects excluded targets. The average of incorporated genes was 56.88%, shown by the red line, which indicates that more than half of the targets were fit into the research. The raw data are shown in detail in Table S13. (B) Significance level of coherence (SLC, -Log10 P) of target intersections between remedies and SSMs are shown in each pixel. SSMs are shown on the left. Remedies are shown above and are divided into 3 scopes, 300-500, 500-900 and 900-1300, indicating the target number. The depth of color represents the value of SLC (-log10 P). The legend is shown on the right; the blue notes indicate fewer than 1000 targets, while the green notes indicate more than 1000 targets. Colors covering different remedies indicated the corresponding course and whether it was from original or clinical remedies, including green was prevention, yellow was symptom onset, orange indicated the confirmed and developed, red was critical stage, purple was the recovery stage, and brown represented some specific basic recipes. These are all shown at the bottom of the heat map. The raw data are presented in Table S14. (C) The top 5 remedies with the best SLC for each SSM are shown. These top 5 formulas that interacted within 14 SSMs were ranked in the upper right corner. Every point refers to one remedy whose shape and line color means which course it was. Specifically, the formulas represented by purple diamonds were used for the recovery stage, e.g., SMI (Shengmai injection); green asterisks were used for prevention, e.g., LSY (the preventive prescription from Liu Shangyi TCM master); orange squares were used for the confirmed and developed stages, e.g., HSBD (Huashibaidu decoction); red triangles were used for to the critical stage, e.g., XBJI (Xuebijing injection); and the brown circle represents basic prescriptions, e.g., HXZQ (Huoxiangzhengqi capsule). (D) Top 3 remedies that impacted more than 1000 genes are shown. The legend is similar to that of C, except that the yellow diamonds were used for symptom onset, e.g., JHQG (Jinhuaqinggan Granule).