Table 3.
The significant level of coherence (SLC) of the top 10 herbs correlated with COVID-19 on the target gene basis
| NO. | Herbs | Number of Herb Targets | COVID-19 Genes | Number Overlapping | P Value | -Log10 P |
|---|---|---|---|---|---|---|
| 1 | Radix Glycyrrhizae (甘草, Gan Cao) | 311 | 172 | 62 | 1.22E-36 | 35.92 |
| 2 | Flos Lonicerae (金银花, Jin Yin Hua) | 382 | 172 | 65 | 4.20E-30 | 29.38 |
| 3 | Fructus Forsythiae (连翘, Lian Qiao) | 356 | 172 | 62 | 9.91E-30 | 29.00 |
| 4 | Herba Agastaches (藿香, Huo Xiang) | 302 | 172 | 54 | 7.28E-27 | 26.14 |
| 5 | Radix Astragali seu Hedysari (黄芪, Huang Qi) | 325 | 172 | 54 | 7.15E-24 | 23.15 |
| 6 | Semen Armeniacae Amarum (杏仁, Xing Ren) | 298 | 172 | 51 | 1.25E-23 | 22.90 |
| 7 | Radix Scutellariae (黄芩, Huang Qin) | 230 | 172 | 40 | 5.04E-19 | 18.30 |
| 8 | Herba Ephedrae (麻黄, Ma Huang) | 889 | 172 | 82 | 1.76E-11 | 10.75 |
| 9 | Rhizoma Phragmitis (芦根, Lu Gen) | 125 | 172 | 18 | 9.22E-07 | 6.04 |
| 10 | Gypsum Fibrosum (石膏, Shi Gao) | 12 | 172 | 3 | 0.001455 | 2.84 |
The SLC is shown as -Log10 P, which was calculated by Chi-squared test. Here, we show crucial data, including herb name, herb target number, COVID-19 genes, number overlapping, p value and -Log10 P. These targets were all constrained with the TCMSP database. The herb targets were all from TCMSP, except for the unlisted Gypsum Fibrosum (12 targets were left out of 19 targets). COVID-19 target genes were obtained from NCBI and GeneCards (172 target genes remained out of 352 targets). The P value is shown in scientific notation. The data are partly shown in Fig. 3A.