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A graphical overview of GR function under normoxia or hypoxia, and the role ofmicroRNA103/107 and KLF4. Left: GR transactivation of targets such as IL6ST, and BATF under normoxia, where the KLF4 binding motif was identified by our ChIP-seq analysis. Right: Hypoxia drives expression of both microRNAs 103 and 107 (miR103 and miR107), which represses KLF4 expression (as shown in panel A), and inhibits multiple GR co-modulators, including CARM1 and NCOA2, as shown in panel B.
