Figure 3.

Effect of lncAMPC Knockdown or Overexpression on Xenograft Tumor Growth and Metastasis In Vivo

(A) The growth curve and harvested specimen of PC-3 subcutaneous xenograft tumors transfected with in vivo NCsi or silncAMPC-2 (n = 4). (B) The growth curve and harvested specimen of PC-3 subcutaneous xenograft tumors stably expressing lncAMPC-OV or NC-OV (n = 4). (C) The IHC analysis (Ki67 and PCNA) of tumors from subcutaneous xenograft models. (D) The liver specimen harvested from the subcutaneous xenograft models above and its H&E staining. (E) Luciferase signal intensities and representative images of mice over time after tail vein injection with PC-3 stably expressing lncAMPC-OV or NC-OV (n = 6). (F) The H&E staining of the liver and lung specimen harvested from the tail-vein-injection xenograft models above. Results are presented as mean ± SD. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.