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. 2020 Nov 6;11(11):957. doi: 10.1038/s41419-020-03151-z

Fig. 6. Age-dependent immune profiling of COVID-19 patients.

Fig. 6

Bar-charts showing HT, days (A), ESR, mm/h (B) and antithrombin III, % (C) in younger (<60, light gray) or older (>60, dark gray) COVID-19 patients. Bar-charts showing T lymphocyte percentage (CD3+ T cells) in healthy (red), age-matched controls and COVID-19 patients (gray) (D), or in younger (<60, light gray) or older (>60, dark gray) COVID-19 patients (E). FACS analysis of immune cell subsets in younger (<60) and older (>60) COVID-19 patients. Bar-charts showing the Percentage of total CD8+ (F) or CD4+ (G) lymphocytes and the expression of TIM3, ICOS, and PD1 in younger (<60, light gray) or older (>60, dark gray) (H–I) COVID-19 patients; the percentage of NK and NKT cells in healthy age-matched controls and COVID-19 patients (L); the percentage of NKT and NK cells in younger (<60) and older (>60) COVID-19 patients (M); NKG2A expression in NK cells in healthy age-matched controls or COVID-19 patients (N) and in younger (<60) or older (>60) COVID-19 patients (O); the percentage of CD11b+ myeloid cells in healthy age-matched controls and COVID-19 patients (P) and in younger (<60) or older (>60) COVID19 patients (Q); the percentage of classical CD11b+CD14highCD16 (R), and non-classical CD11b+CD14lowCD16+ (S) monocytes, and LD-PMN CD11b+HLA-DRlownegCD14CD15+CD66b+ (T) in younger (<60) or older (>60) COVID-19 patients. Data are represented as mean of the percentage of parent population ± SEM. Gating strategy in Fig S6. Mann-Whitney test; *p < 0.05, **p < 0.01, ****p < 0.0001. Healthy N = 11, COVID-19 Patients = 10 (<60 N = 5, >60 N = 5).