Table 3. Gene sets enriched in POLR3G high expression phenotype.
| Gene set | NES | NOM P value | FDR q value |
|---|---|---|---|
| IL6 JAK STAT3 signaling | 2.83 | <0.001 | <0.001 |
| Allograft rejection | 2.72 | <0.001 | <0.001 |
| mTORC1 signaling | 2.7 | <0.001 | <0.001 |
| Protein secretion | 2.69 | <0.001 | <0.001 |
| Inflammatory response | 2.67 | <0.001 | <0.001 |
| Glycolysis | 2.58 | <0.001 | <0.001 |
| Heme metabolism | 2.56 | <0.001 | <0.001 |
| Mitotic spindle | 2.53 | <0.001 | <0.001 |
| Androgen response | 2.46 | <0.001 | <0.001 |
| Interferon-γ response | 2.46 | <0.001 | <0.001 |
| TNF-α signaling via NF-kB | 2.44 | <0.001 | <0.001 |
| PI3K AKT mTOR signaling | 2.42 | <0.001 | <0.001 |
| G2M checkpoint | 2.36 | <0.001 | <0.001 |
| Hypoxia | 2.34 | <0.001 | <0.001 |
| UV response down | 2.32 | <0.001 | <0.001 |
| Apical junction | 2.28 | <0.001 | <0.001 |
| Kras signaling up | 2.28 | <0.001 | <0.001 |
| Complement | 2.28 | <0.001 | <0.001 |
| Myc targets v1 | 2.22 | <0.001 | <0.001 |
| Unfolded protein response | 2.18 | <0.001 | 0.006 |
| UV response up | 2.08 | <0.001 | 0.011 |
| IL2 STAT5 signaling | 2.06 | <0.001 | 0.015 |
| Interferon-α response | 2.03 | <0.001 | 0.014 |
| Epithelial mesenchymal transition | 2.03 | <0.001 | 0.014 |
| E2F targets | 2.03 | <0.001 | 0.013 |
| Apoptosis | 2.02 | <0.001 | 0.013 |
| TGF-β signaling | 2.02 | <0.001 | 0.012 |
| Adipogenesis | 2 | <0.001 | 0.012 |
| Coagulation | 1.96 | <0.001 | 0.015 |
| Reactive oxygen species pathway | 1.88 | <0.001 | 0.026 |
| P53 pathway | 1.87 | <0.001 | 0.03 |
| Fatty acid metabolism | 1.87 | <0.001 | 0.029 |
| Estrogen response early | 1.84 | <0.001 | 0.028 |
| Myc targets v2 | 1.83 | <0.001 | 0.027 |
| DNA repair | 1.77 | <0.001 | 0.035 |
| Oxidative phosphorylation | 1.77 | <0.001 | 0.034 |
| Angiogenesis | 1.66 | <0.001 | 0.056 |
| Apical surface | 1.62 | <0.001 | 0.057 |
| Spermatogenesis | 1.59 | <0.001 | 0.065 |
| Estrogen response late | 1.57 | <0.001 | 0.076 |
| Cholesterol homeostasis | 1.46 | <0.001 | 0.087 |
Notes.
- NES
- normalized enrichment score
- NOM P value
- nominal P value
- FDR
- false discovery rate