Table 4.
Overview of all included studies investigating effects of changes in physiological parameters.
| Type of experiment | Sub-type of Experiment | References | Intervention | Observation | Comments observational studies | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Interventional/observational study |
hypoxic gas Mixture |
Hyperoxic gas mixture |
hypercapnic gas Mixture *measured 20 min after exposure |
Hypocapnia (induced by hyperventilation) |
Hyperoxic and hypercapnic gas mixture *measured 20 min after exposure |
Apnoea results for room air, *also for hyperoxic/hyper-capnic/combinded hyperoxic and hypercapnic inspiratory gas mixes |
Arterial blood pressure decrease |
Arterial blood pressure increase |
Body temperature |
Normovolemic haemodilution |
paO2/*SpO2 | pa CO2 | pH |
Respiratory rate *plus waveform and waveform derivative |
Arterial blood pressure |
Heart rate*plus waveform and waveform derivative |
Body temperature | ||||
| Baseline BOLD signal | Baskerville et al. (2011) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Brevard et al. (2003) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Dunn and Swartz (1997) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Dunn et al. (1999) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Duong (2007) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Graham et al. (1994) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Houston et al. (2000) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Kalisch et al. (2001) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Kannurpatti and Biswal (2004) | i | y/y/y/not investigated | ||||||||||||||||||
| Baseline BOLD signal | Kannurpatti et al. (2002) | i | y/y/not investigated/not investigated | ||||||||||||||||||
| Baseline BOLD signal | Kannurpatti et al. (2003a) | i | n | p | y | y/y/y/n | |||||||||||||||
| Baseline BOLD signal | Kannurpatti et al. (2003b) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Kida et al. (1996) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Lin et al. (1998a) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Lin et al. (1998b) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Lin et al. (1998c) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Lowry et al. (2010) | i | p | p | |||||||||||||||||
| Baseline BOLD signal | Lu et al. (2009) | i | y | p | |||||||||||||||||
| Baseline BOLD signal | Luo et al. (2003) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Prielmeier et al. (1993) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Prielmeier et al. (1994) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Qiao et al. (2007) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Sicard and Duong (2005) | i | y | y | y | ||||||||||||||||
| Baseline BOLD signal | Sicard et al. (2003) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Tuor et al. (2002) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Tuor et al. (2007) | i | p | ||||||||||||||||||
| Baseline BOLD signal | Vanhoutte et al. (2006) | i | y | ||||||||||||||||||
| Baseline BOLD signal | Wang et al. (2006) | i | y | y | |||||||||||||||||
| Baseline BOLD signal | Zaharchuk et al. (1999) | i | n | ||||||||||||||||||
| Baseline BOLD signal | Tsurugizawa et al. (2016) | o | n | ||||||||||||||||||
| Baseline BOLD signal | Xu et al. (2000) | o | y | y | |||||||||||||||||
| Baseline BOLD signal | Sedlacik et al. (2015) | i | y | y | |||||||||||||||||
| periph. stim. |
Electrical | Bock et al. (1998) | i | *no persistent effect | |||||||||||||||||
| periph. stim. |
Electrical | Dutka et al. (2002) | i | *no persistent effect | |||||||||||||||||
| periph. stim. |
Electrical | Hempel et al. (1999) | i | p | |||||||||||||||||
| periph. stim. |
Electrical | Herman et al. (2007) | i | y | |||||||||||||||||
| periph. stim. |
Electrical | Hsu et al. (1998) | i | y | |||||||||||||||||
| periph. stim. |
Electrical | Huang et al. (2013) | i | y | |||||||||||||||||
| periph. stim. |
Electrical | Nasrallah et al. (2015) | i | y | y | y | |||||||||||||||
| periph. stim. |
Electrical | Qiao et al. (2007) | i | p | |||||||||||||||||
| periph. stim. |
Electrical | Sicard and Duong (2005) | i | p | n | p | |||||||||||||||
| periph. stim. |
Electrical | Tuor et al. (2007) | i | p | |||||||||||||||||
| periph. stim. |
Electrical | Wang et al. (2006) | i | n | y | ||||||||||||||||
| periph. stim. |
Mechanical visceral | Min et al. (2011) | o | y | |||||||||||||||||
| periph. stim. |
Electrical | Ramos-Cabrer et al. (2005) | o | y | |||||||||||||||||
| periph. stim. |
Electrical | Sumiyoshi et al. (2012) | o | n | n | n | n | n | |||||||||||||
| periph. stim. |
Chemical somato-sensory | Tuor et al. (2002) | o | p | |||||||||||||||||
| periph. stim. |
Electrical | Schroeter et al. (2014) | o | y | y | Relation not quantitatively analysed | |||||||||||||||
| periph. stim. |
Electrical | Schlegel et al. (2015) | o | x | x | Randomised single pulse stimuli instead of block stimulation no changes in physiological parameters and more specific activation maps | |||||||||||||||
| periph. stim. |
Electrical | Schroeter et al. (2017) | o | x | x | Bilateral responses to unilateral hindpaw stimulation in acallosal mice | |||||||||||||||
| Central stim. | phMRI | Kalisch et al. (2005) | i | y | |||||||||||||||||
| Central stim. | phMRI | Schmidt et al. (2006) | o | n | n | n | |||||||||||||||
| Central stim. | phMRI | Luo et al. (2003) | o | n | |||||||||||||||||
| Resting state | Nasrallah et al. (2015) | i | y | p | p | ||||||||||||||||
| Resting state | Kannurpatti et al. (2008) | i | y | ||||||||||||||||||
| Resting state | Kalthoff et al. (2011) | o | n* | p* | p* | n | |||||||||||||||
References are grouped by type of fMRI; studies which have examined effects on several types of fMRI are highlighted in dark gray on their second appearance. Black = rat studies, blue = mouse studies. y = yes, i.e., a clear effect was observed; p = partial, i.e., effects on some, but not all aspects of the respective outcome were found, or the statistical significance of quantitative results was not indicated or discussed; n = no, i.e., no effect was observed; x = see comment for explanation.
*
In the results field: consult top row of the table for interpretation.