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. 2020 Sep 14;18:118. doi: 10.1186/s12915-020-00848-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Nlgn1^−/− mice display normal associative learning. a–c Pairwise visual discrimination learning task. a Stimuli used, S+ (rewarded stimulus), S−(unrewarded stimulus). b Number of trials to reach learning criterion; two-way ANOVA, values represent means ± SEM. Percentage (%) of mice reaching learning criterion across sessions. c Effect of genotype, session, and their interaction on correct responding, GLLAMM (logistic link function), **p < 0.005 significantly different from 1, values represent the estimated effect of the variables on the odds of correct responding (odds ratio) ± 95% CI. d–f Object-location paired associate learning task. d Visual stimuli and their paired correct locations (6 possible trial types). e Visuospatial learning curve showing performance accuracy across sessions, values represent means ± SEM. f Effect of genotype, session, and their interaction on correct responding, GLLAMM (logistic link function), **p < 0.005 significantly different from 1, values represent odds ratio ± 95% CI