Figure 5.

Prognostic value of epigenetic age acceleration in early stage HCC. (a) Kaplan-Meier curve with log-rank test demonstrates that patients belonging to DNAmAge-ACC showed significantly favorable prognosis regarding overall survival (OS). (b) Epigenetic age acceleration was further discretized into quartiles: Q1 (−58.0, −18.0), Q2 (−18.0, −5.7), Q3 (−5.7, 7.3), Q4 (7.3, 46.9), and rates of (b) OS also well-distinguished. (c) The association between epigenetic age acceleration and the fatality risk of early stage HCC when adjusted for chronological age (binary) and tumor stage was presented with cubic spline graph of the adjusted HR (solid red line) and 95% CI (dotted black line). Knots: −29.4 (10^th), −5.7 (50^th), and 18.9 (90^th) of the distribution of epigenetic age acceleration; reference value: 0, which means that DNAm age equals to chronological age