Table 3.
Particle Size, PDI, ZP and Drug Retention % of ZT-Loaded NLC Aqueous Dispersions (F8) Stored at Refrigerated (5 ± 3°C) and Ambient (25 ± 2°C/40 ± 5% RH) Conditions (See Table 2 for F8 Composition)
| Storage Time | Evaluation Parameters | |||||||
|---|---|---|---|---|---|---|---|---|
| Refrigerated Temperature (5 ± 3 °C) | Ambient Temperature (25 ± 2 °C/40% RH ± 5%) | |||||||
| Particle Size (nm) | PDI | ZP (mV) | Drug Retention (%) | Particle Size (nm) | PDI | ZP (mV) | Drug Retention (%) | |
| Zero time | 394.17 ± 23.45 | 0.129 ± 0.092 | −27.59± 0.1 | 100 ± 0.00 | 394.17 ± 23.45 | 0.129 ± 0.092 | −27.59 ± 0.1 | 100 ± 0.00 |
| 1 month | 382.23 ± 23.41 | 0.193 ± 0.029 | −25.23± 0.87 | 99.17 ± 0.81 | 741.67 ± 10.41*** | 0.265 ± 0.014 | −16.17 ± 0.5*** | 97.89 ± 2.31 |
| 2 months | 349.73 ± 5.87 | 0.186 ± 0.028 | −21.52± 2.54*** | 98.17 ± 8.29 | 817.42 ± 19.73*** | 0.35 ± 0.068** | −12.47 ± 0.15*** | 97.42 ± 7.63 |
| 3 months | 377.75 ± 19.21 | 0.135 ± 0.054 | −24.23± 0.33 | 98.92 ± 3.22 | 947.32 ± 10.43*** | 0.38 ± 0.039** | −14.82 ± 0.26*** | 95.61 ± 4.21 |
Notes: Each measurement was mean of three determinations ± S.D. **Highly significant at p < 0.01 monthly vs initial. ***Extremely significant at p < 0.001 monthly vs initial.