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. 2020 Nov 2;13:11193–11209. doi: 10.2147/OTT.S274092

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© 2020 Zheng et al.

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Expression of let-7c-5p in ESCC and its clinical significance. (A) Reduced mRNA expression of let-7c-5p in 50 pairs of ESCC tissues compared to adjacent normal tissues by qRT-PCR. (B) Decreased mRNA expression of let-7c-5p in five ESCC cell lines (TE-1, TE-10, TE-11, KYSE140 and KYSE150) compared to normal esophageal epithelial Het-1A cells by qRT-PCR. (C) Reduced mRNA expression of let-7c-5p in late stage ESCC tissues compared to early stage ESCC tissues by qRT-PCR. (D) Attenuated mRNA expression of let-7c-5p in ESCC tissues with lymph node metastasis compared to those without metastasis by qRT-PCR. (E) ROC curve analysis of the let-7c-5p assay ratio for discrimination between all ESCC patients and normal controls. (F) Comparison of the diagnostic ability of let-7c-5p in early stage and late stage ESCC by ROC curve analysis. All results are shown as the mean ± SD of three separate experiments (n=3). Statistical analysis was performed with Student’s t-test. *p < 0.05 and **p < 0.01.